Randomized Trialhigh evidence

NSAID ingestion augments training-induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men.

The Journal of physiology·October 26, 2025·PMID 41139248

Why it matters

NSAID use is common among athletes, yet its effects on training adaptations are unclear. This study suggests that while NSAIDs may augment muscle growth, they do not enhance strength, raising questions about their utility for performance.

Infographic summary of NSAID ingestion augments training-induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men.
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