Randomized Trialhigh evidence
Axillary Surgery in Breast Cancer - Primary Results of the INSEMA Trial.
The New England journal of medicine·March 13, 2025·PMID 39665649
Why it mattersThis large, randomized trial provides high-level evidence that surgical axillary staging may be safely omitted in selected patients with early, clinically node-negative breast cancer, potentially sparing many women from lymphedema and arm dysfunction without compromising oncologic outcomes.

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