Basic Sciencemoderate evidence
Mechanobiologically-optimized non-resorbable artificial bone for patient-matched scaffold-guided bone regeneration.
Nature communications·October 24, 2025·PMID 41136443
Why it mattersCritical-sized bone defects, especially in load-bearing sites like the mandible, currently rely on bone grafts and metal plates that cause stress shielding, hardware failure, and interfere with imaging and radiotherapy. This scaffold technology offers a permanent, mechanically optimized solution that promotes bone regeneration without these drawbacks, potentially improving outcomes in complex craniofacial reconstruction.
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