Randomized Trialhigh evidence
Interventions for methamphetamine use among people on methadone maintenance treatment in Vietnam: a sequential multiple assignment randomized trial (STAR-OM).
The Lancet regional health. Southeast Asia·May 1, 2026·PMID 42080150
Why it mattersMethamphetamine co-use undermines methadone treatment for opioid use disorder. This trial provides a structured, evidence-based adaptive intervention model that can be integrated into methadone clinics to sequentially escalate care based on patient response, improving outcomes in a challenging dual-use population.
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