Cohort Studymoderate evidence
Disrupted erythrocyte S1P-eNOS axis promotes hypoxia, hypertension and fibrosis in obstructive sleep apnoea-hypopnoea syndrome.
European heart journal·July 7, 2026·PMID 42412527
Why it mattersIt identifies a novel RBC-centered mechanism linking intermittent hypoxia to systemic vascular injury in OSAHS, offering potential early biomarkers (sphingosine, S1P, arginine) and therapeutic targets beyond CPAP for cardiovascular and renal protection.
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