Randomized Trialhigh evidence
Vagus nerve-mediated neuroimmune modulation for rheumatoid arthritis: a pivotal randomized controlled trial.
Nature medicine·January 1, 2026·PMID 41429981
Why it mattersThis is the first pivotal RCT demonstrating that a neuroimmune intervention can improve RA disease activity, offering a non-pharmacologic option for patients with refractory disease. It validates the inflammatory reflex as a therapeutic target.
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