Randomized Trialhigh evidence
In mechanically ventilated ICU patients, low vs. high physical restraint use did not differ for days free of delirium or coma at 14 d.
Annals of internal medicine·July 1, 2026·PMID 42407074
Why it mattersPhysical restraint use is common in ICUs but its impact on delirium and coma is unclear. This trial provides high-level evidence that a strategy of minimizing restraints does not improve these neurocognitive outcomes, informing restraint policies in emergency and critical care settings.
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