Randomized Trialhigh evidence
Antithrombotic Therapy After Left Atrial Appendage Occlusion: The SIMPLAAFY Randomized Clinical Trial.
JAMA·November 2, 2026·PMID 42970643
Why it mattersPost-LAAC antithrombotic management lacks consensus, and current regimens often involve dual antiplatelet therapy with notable bleeding risk. This trial provides randomized evidence that simpler regimens—aspirin alone or reduced-dose NOAC—are noninferior for ischemic and bleeding outcomes, potentially reducing bleeding complications without sacrificing efficacy.
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