Meta-Analysishigh evidence
Glycemic and cardiometabolic effects of rare sugars allulose and tagatose: a systematic review and meta-analysis of controlled human intervention trials.
The American journal of clinical nutrition·June 1, 2026·PMID 41985675
Why it mattersRare sugars like allulose and tagatose are emerging as potential sugar substitutes, but their metabolic effects require rigorous evaluation. This meta-analysis quantifies their acute postprandial benefits and highlights tagatose's possible longer-term glycemic advantage, informing clinical discussions on sugar alternatives for patients with dysglycemia.
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