Randomized Trialhigh evidence
Cytisinicline for 6 or 12 wk increased smoking cessation rates after treatment and up to 24 wk.
Annals of internal medicine·September 1, 2025·PMID 40889365
Why it mattersCytisinicline offers a potential new pharmacotherapy option for smoking cessation, which is relevant for pain specialists managing patients where smoking worsens outcomes and complicates treatment.

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