Randomized Trialhigh evidence
Early Use of Norepinephrine in High-risk Patients Undergoing Major Abdominal Surgery: A Randomized Controlled Trial.
Anesthesiology·November 1, 2025·PMID 40758953
Why it mattersIntraoperative hypotension is common and linked to poor outcomes. This trial provides evidence that a proactive vasopressor strategy with norepinephrine at induction may reduce complications in high-risk abdominal surgery patients, challenging the traditional reactive approach with ephedrine.
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