Meta-Analysishigh evidence
Treatment strategies for functional hypogonadism in obese men: a systematic review and network meta-analysis.
The journal of sexual medicine·August 5, 2026·PMID 42704281
Why it mattersObesity-related functional hypogonadism is common and reversible, yet comparative efficacy and safety of available treatments have been unclear. This analysis provides outcome-specific effect estimates to guide individualized therapy, highlighting that combining TRT with lifestyle intervention may offer the greatest hormonal and sexual benefits, while glycemic control remains unimproved by any strategy.
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