Randomized Trialhigh evidence

Bimagrumab plus semaglutide alone or in combination for the treatment of obesity: a randomized phase 2 trial.

Nature medicine·March 1, 2026·PMID 41772149

Why it matters

Combining an agent that preserves muscle while reducing fat with a GLP-1 agonist could address concerns about lean mass loss during weight reduction, potentially improving long-term metabolic health and functional outcomes.

Infographic summary of Bimagrumab plus semaglutide alone or in combination for the treatment of obesity: a randomized phase 2 trial.
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