Cohort Studymoderate evidence
The effect of physical activity on brain structure and cognitive function in the population-based cohort of LIFE-Adult Study.
eLife·July 15, 2026·PMID 42454378
Why it mattersThe widely held assumption that physical activity protects brain structure and cognition is challenged by these null findings from a large, well-characterized cohort. Clinicians in neurology and performance longevity should be aware that self-reported activity may be unreliable in older adults, and that observed brain changes may drive activity levels rather than the reverse.
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