Randomized Trialmoderate evidence
Multi-Omics Reveals Mechanisms of Metabolic Rejuvenation in Aged Mice and Pre-Frail Older Men by Losartan.
Aging cell·May 1, 2026·PMID 42017270
Why it mattersAging drives metabolic decline and frailty, and interventions that partially reverse age-related metabolomic changes could inform strategies to extend healthspan. This study provides multi-species evidence that losartan, a widely used antihypertensive, may promote metabolic rejuvenation, offering a potential repurposing opportunity for longevity-focused care.
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