Randomized Trialhigh evidence
Efficacy and Safety of Seltorexant in Insomnia Disorder: A Randomized Clinical Trial.
JAMA psychiatry·August 13, 2025·PMID 40802194
Why it mattersSeltorexant offers a novel mechanism for insomnia with sustained efficacy and favorable tolerability, potentially addressing limitations of current treatments like zolpidem, which showed diminished effects over time.
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