Randomized Trialhigh evidence
Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial.
Nature aging·November 1, 2025·PMID 41174221
Why it mattersAge-related immune decline increases infection and cancer risk, yet no clinical interventions directly target it. This trial provides early human evidence that a mitophagy inducer can modulate immune cell composition and function, opening a potential avenue for longevity-focused therapies.
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