Randomized Trialhigh evidence
Memantine for Premature Atrial Contractions: A Phase 2 Randomized Clinical Trial.
Circulation·April 21, 2026·PMID 41853846
Why it mattersPACs are linked to atrial fibrillation, stroke, and heart failure, yet no approved therapy exists. This trial provides proof-of-concept for a non-ion channel approach targeting the cardiac glutamatergic system, potentially opening a new therapeutic class for atrial ectopy.
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