Randomized Trialhigh evidence
A Randomized Clinical Trial of Dexmedetomidine on Delirium, Cognitive Dysfunction, and Sleep After Non-Ambulatory Orthopedic Surgery With Regional Anesthesia.
Anesthesia and analgesia·January 1, 2026·PMID 40403182
Why it mattersPostoperative neuropsychiatric complications are common and impactful in older surgical patients. This trial provides strong evidence that dexmedetomidine sedation during regional anesthesia can markedly reduce these events, offering a practical strategy for anesthesiologists and pain specialists to improve perioperative outcomes.
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