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Use of Predicted Risk and Expected Benefit to Guide Decision-Making in Cardiovascular-Kidney-Metabolic Syndrome for the Primary Prevention of Cardiovascular Disease: A Scientific Statement From the American Heart Association and American College of Cardiology.

Circulation·June 9, 2026·PMID 42263147

Why it matters

This statement provides a unified framework for cardiologists and internists to move beyond single-disease risk assessment, addressing the clustering of cardiovascular, kidney, and metabolic risks. It operationalizes how to use the latest risk equations to personalize preventive therapy decisions and improve population-level outcomes.

Infographic summary of Use of Predicted Risk and Expected Benefit to Guide Decision-Making in Cardiovascular-Kidney-Metabolic Syndrome for the Primary Prevention of Cardiovascular Disease: A Scientific Statement From the American Heart Association and American College of Cardiology.
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