Randomized Trialhigh evidence
Stent Retriever Thrombectomy in Patients With Myocardial Infarction The Open-label, Multicenter NATURE Superiority trial.
Journal of the American College of Cardiology·August 29, 2026·PMID 42670735
Why it mattersPatients with STEMI and large thrombus burden have worse outcomes, and current PCI strategies often leave residual thrombus. This trial provides evidence that mechanical thrombectomy with a stent retriever can reduce infarct size, a surrogate for mortality and heart failure, potentially improving long-term prognosis in this high-risk subgroup.
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