Randomized Trialhigh evidence
Effect of engineered mesoporous silica particles with tailored pore size on glycaemic control in individuals with prediabetes or type 2 diabetes: a randomised, double-blind, placebo-controlled SHINE trial.
EClinicalMedicine·July 1, 2026·PMID 42433278
Why it mattersPrediabetes progression to type 2 diabetes remains a major clinical challenge, with lifestyle interventions often limited by adherence. SiPore21 offers a novel, non-pharmacological, gut-localized mechanism—entrapping digestive enzymes—that may address both glycemia and weight, providing a potential new tool for metabolic management.
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