Meta-Analysismoderate evidence

Efficacy and safety of psilocybin-assisted therapy for alcohol use disorder: A systematic review and meta-analysis.

Journal of psychopharmacology (Oxford, England)·October 8, 2026·PMID 42850948

Why it matters

Alcohol use disorder remains difficult to treat, with high relapse rates and limited pharmacologic options. This meta-analysis provides preliminary evidence that psilocybin-assisted therapy may reduce drinking and support abstinence, offering a potential novel treatment pathway for addiction specialists and psychologists.

Infographic summary of Efficacy and safety of psilocybin-assisted therapy for alcohol use disorder: A systematic review and meta-analysis.
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