Cohort Studyhigh evidence
Frailty and accelerated dementia onset in genetic, sociodemographic and neuropathologic subgroups.
Journal of neurology, neurosurgery, and psychiatry·July 21, 2026·PMID 42481072
Why it mattersFrailty may independently lower the threshold for clinical dementia expression, particularly when neurodegenerative pathology is mild. Routine frailty assessment could improve risk stratification and identify older adults who might benefit from targeted interventions to delay cognitive decline.
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