Mechanical Thrombectomy Versus Systemic Thrombolysis in Hemodynamically Unstable High-Risk Pulmonary Embolism Requiring Vasopressors: A Propensity-Matched Outcomes Analysis From TriNetX Network.

Journal of the Society for Cardiovascular Angiography & Interventions·September 1, 2026·PMID 42769895

Why it matters

High-risk PE with hemodynamic instability carries high mortality, and the optimal reperfusion strategy remains debated. Systemic thrombolysis, while standard, increases intracranial bleeding risk. This real-world analysis suggests mechanical thrombectomy may offer a survival advantage and fewer strokes, informing urgent decision-making in critical care and emergency settings.