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Effect of age on the association between oxygen exposure and mortality in ARDS: a secondary analysis of randomized controlled trials with independent multicenter evaluation.

Anaesthesia, critical care & pain medicine·November 4, 2026·PMID 42982124

Why it matters

Clinicians often assume FiO2 up to 60% is safe, but this study suggests mortality risk rises linearly with oxygen exposure in ARDS, regardless of patient age.

Infographic summary of Effect of age on the association between oxygen exposure and mortality in ARDS: a secondary analysis of randomized controlled trials with independent multicenter evaluation.
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