Systematic Reviewhigh evidence
Benefits and Harms of Pharmacologic Treatments in Adults With Overweight or Obesity: A Living Systematic Review and Network Meta-analysis for the American College of Physicians.
Annals of internal medicine·June 16, 2026·PMID 42296503
Why it mattersThis comprehensive synthesis provides comparative effectiveness data on a rapidly expanding class of weight-management drugs, helping clinicians choose among agents based on weight loss efficacy, cardiovascular benefits, and tolerability.

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