Meta-Analysishigh evidence
High-Flow Nasal Oxygen Versus Conventional Oxygen Therapy and Non-Invasive Ventilation for Acute Respiratory Failure in the Emergency Department: A Systematic Review and Meta-Analysis.
Emergency medicine Australasia : EMA·October 1, 2026·PMID 42728228
Why it mattersAcute respiratory failure in the ED often requires escalation to invasive ventilation, which carries significant morbidity. This meta-analysis provides pooled evidence that HFNO may reduce intubation rates compared with COT and NIV, particularly in undifferentiated patients, offering a potentially less invasive first-line strategy.
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