Randomized Trialhigh evidence
Whole-brain cholinergic modulation following computerized cognitive training in healthy older adults: a [18F]FEOBV PET study.
GeroScience·August 27, 2026·PMID 42661035
Why it mattersCholinergic decline is a hallmark of cognitive aging, yet scalable interventions to support cholinergic function are lacking. This trial demonstrates that a widely available, non-pharmacological cognitive training program can increase cholinergic terminal density in key attentional and executive regions, suggesting a neurobiological mechanism for cognitive resilience that may inform preventive strategies in aging populations.
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