Meta-Analysishigh evidence
Sex-Related Differences in Outcomes and Thresholds for Intervention in Primary Mitral Regurgitation: A Systematic Review and Meta-Analysis.
JACC. Cardiovascular imaging·July 8, 2026·PMID 42435019
Why it mattersCurrent guideline thresholds for mitral regurgitation intervention may not account for sex-based differences in presentation and outcomes, potentially leading to delayed referral and worse prognosis in women. Understanding that tricuspid valve involvement and age drive mortality disparities can inform more equitable timing and selection for intervention.
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