Cohort Studyhigh evidence
Leveraging a Genetic Proxy to Investigate the Effects of Lifelong Cardiac Sodium Channel Blockade.
Circulation·December 16, 2025·PMID 41277422
Why it mattersIt provides human genetic evidence for the long-term effects of cardiac sodium channel blockade, revealing both antiarrhythmic benefits and risks (e.g., post-MI harm) that are difficult to study in trials. This can inform drug development and risk stratification.
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