Meta-Analysishigh evidence
Association of Metformin Use With Osteoarthritis Incidence, Progression, and Joint Arthroplasty Risk in the Knee and Hip: A Systematic Review and Meta-Analysis.
The Journal of arthroplasty·May 1, 2026·PMID 41067453
Why it mattersOsteoarthritis lacks disease-modifying therapies. This meta-analysis provides pooled clinical evidence that metformin, a widely available and safe drug, may reduce OA incidence and progression, potentially delaying or avoiding joint replacement, especially in high-risk patients with diabetes or obesity.
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