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Randomized Trialhigh evidence

Time-restricted feeding extends healthspan in both sexes and lifespan in male C57BL/6 J mice.

Nature aging·June 1, 2026·PMID 42230994

Why it matters

This study provides controlled evidence that TRF can extend healthspan in both sexes and lifespan in males, even without obesity-promoting diets, highlighting sex as a key modifier of aging interventions.

Infographic summary of Time-restricted feeding extends healthspan in both sexes and lifespan in male C57BL/6 J mice.
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MedLit · Evidence, Distilled