Randomized Trialhigh evidence
Menopausal hormone therapy, migraine history, and headache severity: Results from the Women's Health Initiative Hormone Therapy clinical trials.
Headache·July 8, 2026·PMID 42419355
Why it mattersClinicians managing menopausal symptoms in women with migraine need to weigh the risk of headache exacerbation when prescribing MHT. This trial provides randomized evidence that estrogen-only therapy may be safer for headache, while combined E+P increases headache burden, particularly in those with migraine history.
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