Cohort Studyhigh evidence
Plasma proteomic signatures of cellular aging predict human disease.
Nature medicine·June 1, 2026·PMID 42297981
Why it mattersFor performance and longevity specialists, this paper introduces a proteomic framework to quantify organ- and cell-specific aging, moving beyond whole-body biological age clocks. It identifies actionable vulnerabilities—such as extreme astrocyte or myocyte aging—that dramatically elevate disease risk, enabling earlier risk stratification and targeted intervention.
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