Cohort Studymoderate evidence

Real-world comparative effects of slow-release oral morphine vs. methadone on healthcare use for opioid use disorder: A population-based target trial emulation.

Addiction (Abingdon, England)·July 16, 2026·PMID 42464066

Why it matters

Expanding medication options for opioid use disorder is critical in the fentanyl era. These real-world findings suggest SROM is a viable alternative to methadone without increasing acute healthcare utilization, supporting its use in treatment programs.

Infographic summary of Real-world comparative effects of slow-release oral morphine vs. methadone on healthcare use for opioid use disorder: A population-based target trial emulation.
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