Cohort Studyhigh evidence
Causal Endotype-Based Classification of Myocardial Infarction.
JAMA cardiology·August 29, 2026·PMID 42667602
Why it mattersThe type 1/type 2 MI framework incompletely captures mechanistic heterogeneity and prognosis. This endotype classification reveals distinct clinical profiles and mortality risks, particularly the high noncardiovascular mortality in systemic and cardiac/noncoronary MI, which may inform risk stratification and management beyond coronary-focused care.
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