Metformin attenuates metabolic insulin sensitivity and insulin-stimulated carbohydrate oxidation after high-intensity exercise training in adults at risk for metabolic syndrome.

Diabetes, obesity & metabolism·April 1, 2026·PMID 41532329

Why it matters

For clinicians managing patients at risk for metabolic syndrome, combining metformin with high-intensity exercise may counteract the insulin-sensitizing benefits of exercise alone. This interaction is critical when prescribing lifestyle and pharmacotherapy concurrently.