Randomized Trialhigh evidence
High-Dose Intravenous Vitamin C and Mortality and Organ Dysfunction in Severe Burn Injury: The VICTORY Randomized Clinical Trial.
JAMA·June 10, 2026·PMID 42267875
Why it mattersHigh-dose vitamin C has been used off-label in burn resuscitation based on theoretical anti-inflammatory benefits, but this large multicenter trial provides strong evidence of potential harm, including increased mortality. Emergency physicians and burn care teams should be aware that this intervention is not beneficial and may worsen outcomes.
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