Menopausal status, transition, and age at menopause with accelerated biological aging across multiple organ systems: findings from two cohort studies.

BMC medicine·August 6, 2025·PMID 40770753

Why it matters

Menopausal transition emerges as a critical period of accelerated biological aging, particularly in the liver, metabolic, and kidney systems. For clinicians focused on longevity and healthspan optimization, these findings highlight a window where targeted interventions—such as lifestyle modification, metabolic monitoring, or hormone therapy evaluation—could mitigate organ-specific aging trajectories and improve long-term health outcomes in women.