Cohort Studymoderate evidence
Pulmonary inflammation in severe pneumonia is characterised by compartmentalised and mechanistically distinct sub-phenotypes.
Nature communications·June 23, 2026·PMID 42337236
Why it mattersThese findings reveal that severe pneumonia is not a single biological entity but comprises mechanistically distinct sub-phenotypes with different trajectories. Recognizing these endotypes could eventually guide targeted therapies and improve prognostication in critically ill patients.
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