Randomized Trialhigh evidence
Effect of Baseline ASPECTS on Tenecteplase Efficacy Before Thrombectomy in Acute Large-Vessel Occlusion Stroke: A Post Hoc Analysis of the BRIDGE-TNK Randomized Trial.
Neurology·September 22, 2026·PMID 42623571
Why it mattersSelecting patients for bridging thrombolysis before thrombectomy remains challenging. This analysis suggests that patients with larger baseline ischemic cores (ASPECTS <8) may derive functional benefit from tenecteplase, whereas those with smaller cores may not, and could face higher mortality. These findings could inform patient selection and highlight the need for prospective validation.
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