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Artificial intelligence-enabled clinical phenotyping of human brown fat.

Nature·October 14, 2026·PMID 42875491

Why it matters

Brown fat activity is linked to cardiometabolic protection, but its full clinical spectrum and scalable measurement have been unclear. This large-scale AI approach identifies BAT-associated phenotypes and suggests a repurposable drug target, offering a potential pathway for risk stratification and therapeutic intervention in metabolic and cardiovascular disease.

Infographic summary of Artificial intelligence-enabled clinical phenotyping of human brown fat.
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