Cohort Studyhigh evidence
Intracranial haemorrhage following tenecteplase fibrinolysis for acute myocardial infarction.
European heart journal·September 21, 2026·PMID 42766418
Why it mattersIntracranial hemorrhage is a devastating complication of fibrinolytic therapy for STEMI. Identifying modifiable risk factors—such as systolic blood pressure and tenecteplase dose—can guide safer administration, particularly in older patients and those with lower body weight, where dose adjustment may reduce bleeding risk.

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