Randomized Trialhigh evidence
Collaborative Care for Opioid Use Disorder and Mental Illness: The CLARO Randomized Clinical Trial.
JAMA internal medicine·February 1, 2026·PMID 41460640
Why it mattersCollaborative care is widely endorsed for mental health, but this large pragmatic trial found no added benefit for complex patients with OUD and mental illness in low-resource settings. It challenges assumptions about model generalizability and highlights the need to understand what drives improvement in usual care.
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