Randomized Trialhigh evidence
Activity-dependent adaptive deep brain stimulation improves gait in Parkinson's disease.
Nature medicine·June 15, 2026·PMID 42297979
Why it mattersExisting DBS uses fixed parameters that do not account for fluctuating symptoms during different activities. This adaptive framework could personalize neuromodulation, addressing gait impairments that are often refractory to conventional DBS.

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