Randomized Trialhigh evidence

Activity-dependent adaptive deep brain stimulation improves gait in Parkinson's disease.

Nature medicine·June 15, 2026·PMID 42297979

Why it matters

Existing DBS uses fixed parameters that do not account for fluctuating symptoms during different activities. This adaptive framework could personalize neuromodulation, addressing gait impairments that are often refractory to conventional DBS.

Infographic summary of Activity-dependent adaptive deep brain stimulation improves gait in Parkinson's disease.
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