Randomized Trialhigh evidence
Growth Hormone Replacement Therapy in Heart Failure With Reduced Ejection Fraction: A Randomized, Double-Blind, Placebo-Controlled Trial.
JACC. Heart failure·April 1, 2025·PMID 40047762
Why it mattersGHD is prevalent in HFrEF and linked to worse outcomes, yet it is rarely screened or treated. This trial provides rigorous evidence that GH replacement can improve functional capacity and ventricular function, highlighting a potential adjunctive therapy for a subset of heart failure patients.
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