Meta-Analysishigh evidence
Long-Term Cardiovascular Safety of Testosterone-Replacement Therapy in Middle-Aged and Older Men: A Meta-analysis of Randomized Controlled Trials.
American journal of cardiovascular drugs : drugs, devices, and other interventions·November 1, 2025·PMID 40694252
Why it mattersTRT is widely used for hypogonadism, yet cardiovascular safety concerns persist. This large meta-analysis clarifies that while major adverse cardiac events are not increased, arrhythmia risk is significantly elevated, informing risk-benefit discussions.
The papers that matter, first.
MedLit ranks the medical literature into a specialty feed with concise summaries, evidence-aware triage, and visual takeaways.
§
MedLit · Evidence, Distilled