Basic Sciencemoderate evidence
Hypoxia-induced autophagic degradation of HIF-1α attenuates cellular aging and extends mammalian lifespan.
Nature aging·May 1, 2026·PMID 42120734
Why it mattersIt identifies a novel HIF-1α degradation pathway under hypoxia that promotes longevity, and demonstrates a pharmacological strategy to harness this mechanism systemically, potentially informing future geroprotective interventions.
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