Basic Sciencemoderate evidence
SOX9 switch links regeneration to fibrosis at the single-cell level in mammalian kidneys.
Science (New York, N.Y.)·February 23, 2024·PMID 38386758
Why it mattersIt identifies a molecular switch (SOX9 activity persistence) that determines whether kidney repair is regenerative or fibrotic, offering a potential therapeutic target to prevent chronic kidney disease after acute injury.
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